Aperio ePathology Solutions

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New Study Highlights Improved Pathologist Reader Accuracy Using Aperio ePathology Solutions: NETWORK

Quintiles, the world’s largest CRO, partnered with Amicus to create a novel quantitative method to evaluate inclusions in renal capillaries. The study compared the accuracy of multiple readings made by pathologists using glass slides versus multiple readings made on annotated eSlides using the Aperio NETWORK under a GLP setting.

Accuracy rates using conventional glass slides:

• Pathologist intra-reader accuracy of only 60%.
• Pathologist inter-reader accuracy of only 68%.

Accuracy rates using the Aperio ePathology NETWORK:

• 67% improvement in pathologist intra-reader accuracy, bringing accuracy to 100% relative accuracy with the use of annotated eSlides.
• 37% improvement in pathologist inter-reader accuracy, bringing accuracy to 93% relative accuracy.

Key Excerpt from the Study

“The virtual microscopy–based methodology increases accuracy and reproducibility; moreover, it provides a permanent record of retrievable data with full transparency in clinical trials.”

Reference

Barisoni L., Jennette JC, Colvin R, et al. Novel quantitative method to evaluate globotriaosylceramide inclusions in renal peritubular capillaries by virtual microscopy in patients with Fabry disease. Arch Pathol Lab Med. 2012; In Press. 

It's simple. Just copy the following JavaScript and HTML into your web page at the point where you want the slide to be displayed:

All you need to do is set the dimensions of the viewing window, and the server name and image file where the image is located (highlighted in blue above). Try it. Just another way Aperio puts the power of ePathology at your fingertips.

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DID YOU KNOW!

1. From the moment that glass slides become eSlides, the Aperio NETWORK enables remote, simultaneous, real-time viewing and immediate distribution for consults and collaboration, digital annotation and archival.
2. Using Aperio eSlides for external collaboration (such as between a CRO and biopharma) eliminates shipping costs, travel time and the expense of re-cuts.
3. Aperio ePathology solutions enable you to complete an average pre-clinical study in 50% less time than it would take using traditional capture and analysis methods.
4. Aperio PRECISION TOOLS provide researchers with easy-to-use analytic capability that reduces manual errors and automates tedious manual tasks.
5. Aperio open ePathology platform brings together industry-leading and innovative eSlide analysis tools in one central hub.
6. All precision tools work exactly like the existing Aperio tools and are seamlessly integrated into the Aperio platform - from scanning to storage, you never leave the Aperio environment.
7. Aperio precision analysis tools are integrated with Genie software to automate pattern recognition on tissue sections.
8. The Genie precision analytics tool can significantly reduce the time taken to deliver IHC image analysis.
9. Aperio eSlide Manager™ increases reader accuracy and reproducibility; moreover, it provides a permanent record of retrievable data with full transparency in pre-clinical and clinical trials.
10. The Aperio NETWORK delivers eSlides with unprecedented detail on an interoperable and scalable web-based software platform.